A postdoc position in a project to analyze the role of antibodies and joint proteins in rheumatoid arthritis is now open. It is placed at Southern Medical University, Guangzhou, China and the research will be performed at both SMU and at Karolinska Institutet, Stockholm, Sweden.
Form of employment:
Full-time, 3 years (with a trial employment for 6 months) and with a possibility of prolongation.
Start: as soon as possible.
Apply before: Nov 23, 2015.
Description:
Applications are invited for a position as a postdoc in a project led by Prof. Rikard Holmdahl. The task is to identify, produce and analyse proteins of critical importance for development of rheumatoid arthritis.
Project:
The project aim to basic mechanisms of importance in the development of rheumatoid arthrititis. The test is based on already unique antigenic epitopes derived from various joint proteins and antibodies derived from rheumatoid arthritis patients. The epitopes has been formulate as conformational peptides but needs to be further improved regarding their functional and diagnostic role. As these peptides and epitopes are shared between mice and humans there are possibilities to make in depth functional analysis in the mouse as well as testing of human sera for assay development. The project involves establishment of human monoclonal antibodies and purification of polyclonal antibodies from RA patients. These will be analysed in vitro as well as in mouse models. The identification of new epitopes will require both in depth and large scale biochemistry including HPLC, mass-spectrometrometry and a range of analytical methods. Development and production of recombinant proteins using different expression system The ultimate goal is to contribute to the development of new diagnostic tests and vaccination to prevent the development of rheumatoid arthritis. Results are expected to be published in leading international journals.
Qualifications:
To qualify, the applicant must hold a PhD in medicine or biological science. Fluent English is an absolute requirement as the lab working language is English. Excellence in protein biochemistry is a requirement. Computer skills, bioinformatic knowledge and experience in cellular immunology are needed.
Contact and Application:
Apply directly to Angel Yao Mattisson (Angel.Yao-Mattisson@ki.se). Please mention the job number (MIR-1502) in your application.
Medical Inflammation Research (MIR) 