K.S. Nandakumar

Nan 2

/ medinflam

Specific Aims of Research: Kutty Selva Nandakumar

  1. To understand the pathogenic mechanisms and genes involved at the effector phase of arthritis using IgG antibodies
  2. To study specific cleavage of IgG as new avenue for treating inflammation
  3. To characterize biocompatible and biodegradable thermo-responsive polymers as new adjuvants
  4. To develop vaccine for arthritis by targeting complement factor 5
  5. To explore pathogenic and protective autoantibody interactions with chondrocytes
  6. To investigate how estrogen affects antibody synthesis, glycosylation and effector functions in arthritis

Cartilage

Main Supervisor for Ph.D. student

  1. Gonzalo Fernandez (2014 -) – How estrogen affects antibody synthesis, glycosylation and effector functions in arthritis?

Co-supervisor for Ph.D. students

  1. Gustaf Wigerblad (2011-) – Mechanisms of arthritis induced pain
  2. Erik Lönnblom (2012-) – Environmental factors in arthritis
  3. Alex Bersellini Farinotti (2014 -) – Electrophysiology of pain
  4. Clara Marquina (2014 -) – Positional identification of inflammatory  genes

Mentor for Ph.D. student

  1. Sakthi Vignesh (2014- ) – Department of Women’s and Children’s Health, Karolinska University Hospital

Main Supervisor for Research Student

  1. Daniëlle Vaartjes (Dec 2012 – Mar 2015)

COMPLETED

Postdoctoral fellow

  1. Akilesh Kumar Shakya (June 2012- May 2013) – Characterization of thermoresponsive polymers as adjuvants in arthritis. Present position: Assistant Professor, Texas Tech University, USA.

Ph.D. students

Main Supervision:

  1. Dorota Klaczkowska, 120523, "Finding genes controlling arthritis in mice – Fc gamma receptors and complement C5", Medical Faculty, MBB, Karolinska Institute, opponent Associate Professor Sjef Verbeek, Leiden University, The Netherlands. Present Position: Postdoc, Department of Clinical Science and Education, Sodersjukhuset, Stockholm
  2. Ia Khmaladze: 141208, "Understanding Inflammatory Mechanisms in Rheumatic Diseases",  Karolinska Institutet, opponent Ann Rothstein, University of Massachusetts Medical School, USA. Present Position: Postdoc, Molecular Dermatology, Department of Medicine, Karolinska Hospital, Stockholm.

Co-Supervision:

  1. Ingrid Lindh, 130412, "Autoantibody Recognition of Collagen Type II in Arthritis", Medical Faculty, MBB, Karolinska Institute.

Publications List

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Kutty Selva Nandakumar

/ medinflam

Kutty Selva Nandakumar

IgG  medierad autoimmunitet: Fc Glykosylering, Citrullin igenkänning, Initiering och genidentifikation i Artrit


Autoimmuna sjukdomar uppstår när kroppsvävnad felaktigt attackeras av sitt eget immunsystem. Reumatoid artrit (RA) är en autoimmun sjukdom som angriper lederna och leder till kronisk inflammation. Smärta, svullnad, stelhet och förstörelse av lederna är vanligt och kan leda till minskad rörlighet hos RA patienter. RA drabbar 0,5-1% av världens befolkning. Kvinnor drabbas oftare än män. Vad som orsakar sjukdomen och hur den utvecklas är oklart. Tidigare lyckade behandlingar av RA som har gjorts genom att med antikroppar ta bort B cellerna ger hopp åt lidande patienter. Tack vare framsteg i behandlingen av RA med bortplockande av B-celler har nytt intresse väckts för vilken roll som B-cellerna och antikropparna som de utsöndrar har i utvecklingen av sjukdomen. IgG antikroppar bidrar inte bara till inflammationen associerat med immunkomplex utan kan också ha en direkt nedbrytande effekt på brosket. Syftet med detta projekt är att förbättra vår förståelse för B-cellernas och antikropparnas roll i att framkalla RA vilket kommer att ha betydande inverkan på förmågan att utveckla nya behandlingar för RA och andra autoimmuna sjukdomar orsakade av IgG (t.ex: lupus nephritis, myasthenia gravis). Nyligen utnyttjade vi bakterieenzymet från S. pyogenes, EndoS för att specifikt klyva kolhydrater som finns på Fc delen av den artrit framkallande IgG molekylen och detta ger ett betydande skydd mot artrit. I detta projekt vill vi specifikt klyva Fc kolhydraterna direkt i mössen genom att injicera EndoS och undersöka vilken effekt det har för att förebygga artrit. RA patienter har också höga nivåer av citrullinantikroppar som används i diagnossyfte. Om dessa citrullinspecifika antikroppar har sjukdoms framkallande effekt är inte bevisat och inte heller vet vi hur dessa antikropps producerande B celler väljs ut. I detta projekt vill vi skapa och studera en ny transgen mus som bara producerar anti-citrulline antikroppar för att besvara dessa frågor. Dessutom är djurmodeller nödvändiga för att undersöka hur artrit utvecklas och vilka faktorer som orsakar sjukdomen? Men, djurmodeller som används idag för artrit studier använder ett själv-antigen (t.ex kollagen typ II) blandat med en substans kallad adjuvans för att framkalla sjukdomen. Dessa adjuvanser som används vid injektion stör alltid immunsvaret så att vi inte vet vilket det faktiska immunsvaret mot självantigenet är? I detta projekt vill vi utveckla en ny adjuvans genom att använda smarta, overksamma och väldefinierade kemiska polymerer för att förstå immunsvarets karaktär mot själv-antigen utan att involvera klassiska adjuvanser. Viktigast av allt, för att förstå sjukdomens utvecklande måste vi identifiera de gener som gynnar sjukdomen. I denna riktning kommer vi att identifiera minst en gen som gynnar antikroppsfrämjande artrit under projektperiod. Alltså kommer denna studie att ge resultat som hjälper till att bättre förstå RA sjukdom. Detta föreslagna projekt kommer också att leda till humana studier i denna riktning och eventuellt hjälpa till att utveckla nya effektiva behandlingar för RA patienter och patienter med andra autoimmuna sjukdomar inducerade av IgG antikroppar.

Nan1

/ medinflam

Kutty Selva Nandakumar, Ph.D., Dr.Med.Sci.
Associate Professor (Docent)
Medical Inflammation Research, MBB, Karolinska Institute (KI)

&

Adjunct Faculty of University of Arkansas for Medical Sciences (UAMS)
Little Rock, USA

ADDRESS
Scheeles väg 2 B2, Plan 4, 171 77 Stockholm
Tel: 08-524   86533 (Direct), 0707432769 (mobile),
08-524   87715; 08-524   86337 (lab); Fax: 08-524 87750
e-mail: Nandakumar.Kutty-Selva @ ki.se

URL

EDUCATION

  • 2006 – Doctor of Medical Science (Dr.Med.Sci.) – Medical Inflammation Research – Medical Faculty – Lund University – Sweden
  • 1996 – Doctor of Philosophy (Ph.D.), Department of Immunology – School of Biological Sciences, Madurai Kamaraj University – India
  • 1988 – Master of Science (M.Sc.) – Department of  Medical Biochemistry – PGIBMS – University of Madras – India
  • 1986 – Bachelor of Science (B.Sc.) – Department of Chemistry – Sacred Heart College – University of Madras – India

LAB AND RESEARCH EXPERIENCE

  • Dec 2011 – Associate Professor – Medical Inflammation Research (MIR) – Department of Medical Biochemistry and Biophysics (MBB) – Karolinska Institute (KI) – Sweden
  • Nov  2008 – Nov 2011 – Assistant Professor – MIR – MBB –  KI – Sweden
  • July  2008 – Oct 2008 – Research Scientist – MIR – MBB –  KI – Sweden
  • April 2007 – June 2008 – Research Assistant – LUDC – Lund University (LU) – Sweden
  • Feb 2007 – Mar 2007 – Research Scientist – Hansa Medical AB – LU – Sweden
  • Feb 2006 – Jan 2007 – Research Scientist – Resistentia Pharmaceuticals AB – LU – Sweden
  • June 1998 – May 2001 – Postdoctoral Fellow – MIR – LU – Sweden
  • Jan 1996 – May 1998 – Postdoctoral Fellow – CCMB, India
  • 1988 – 1989 – Project Student – Department of Biochemistry, AIIMS –  India

PARTICIPANT IN EU PROJECTS

COMMISSION OF TRUST

EVALUATION OF PROJECT GRANTS

  • ARC grant (UK) – 2008, 2010, 2011, 2012 and 2014
  • KID grants (KI, Sweden) – VT & HT – 2012, VT & HT – 2013, VT & HT – 2014, 2015
  • Dutch Technology Foundation (STW, The Netherlands) – 2012

MEMBER OF THE EDITORIAL BOARD

  • Dataset Papers in Immunology
  • Dataset Papers in Rheumatology
  • Journal of BioScience and Biotechnology
  • WebMed Central
  • New Journal of Science
  • Autoimmune Diseases & Therapeutic Approaches

ADHOC REFEREE

  • Arthritis Research & Therapy (2004-2016)
  • Evidence-Based Complementary and Alternative Medicine (2016)
  • PLoS One (2015)
  • Journal of Inflammation (2015)
  • Journal of Immunology (2015)
  • International Journal of Biological Macromolecules (2015)
  • Expert Review on Vaccines (2014)
  • Expert Review of Molecular Diagnostics (2014)
  • Expert Review of Clinical Immunology (2014)
  • Journal of Biomaterials Science: Polymer Edition (2014)
  • Vaccines (2014)
  • Scandinavian Journal of Immunology (2010-14)
  • Annals of Rheumatic Diseases (2013)
  • International Journal of Environmental Research and Public Health (2013)
  • Medical Principles and Practice (2013)
  • Molecular Pharmaceutics (2013)
  • Current Organic Chemistry (2013)
  • Apoptosis (2013)
  • European Journal of Immunology (2006-2007, 2011-2012)
  • Langmuir (2009)
  • Mediators of Inflammation (2009)
  • Biotechnology Advances (2009)
  • BMC Musculoskeletal Disorders (2008)
  • Biomaterials (2008)
  • Cytokine (2008)
  • Cancer Biomarkers (2007)
  • Nature Protocols (2006)
  • Scandinavian Journal of Rheumatology (2005)

TEACHER TRAINING

  • 2015 – Open Networking and Learning Course (ONL141) – Karolinska Institute
  • 2014 – Teaching and Learning in Higher Education – Karolinska Institute
  • 2013 – Project leadership for Research leaders – Karolinska Institute
  • 2012 – Pedagogy for Doctoral supervisors – Karolinska Institute
  • 2012 – Web course for Supervisors – Karolinska Institute
  • 2011 – Teaching International Students – Karolinska Institute
  • 2009 – Advanced Course on Communication and Learning – Karolinska Institute
  • 2009 – Postgraduate Supervisor Training Course – Karolinska Institute
  • 2009 – Basic Course in Education for University Teachers – Karolinska Institute
  • 2002 – Basic Course on Oral Communication – Lund University

COURSE ORGANIZER

        (Oct 2011, Mar 2013, Mar 2014, Mar 2015, Mar 2016)

TEACHER

  • Disease models of autoimmunity (arthritis, lupus, asthma)
  • Immunology and genetics for biomedical students
  • Organic chemistry for undergraduate students (GOC)
  • Biochemistry for undergraduate students (MBK)

RESEARCH TRAINER (SHORT DURATION)

M.Sc. students: 4; Ph.D. students: 5; M.D. students: 2; BMA student: 1

JUDGING COMMITTEE CHAIRMAN (Ph.D. Dissertation)

  • Thomas Landgraff Hagglof (Feb 2016) -"iNKT cell regulation of B cell responses in inflammation", Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Sweden.
  • Peter Lundback (Apr 2015) – " HMGB1: Regulation of Inflammatory Functions and Therapeutic Blockade", Centre for Molecular Medicine, Karolinska Institute, Sweden.
  • Chengjun Sun (October 2014) – "A study of Biomarker analysis in association with type I diabetes and their shared features in Rheumatoid arthritis" – Department of Medicine, Karolinska Institute, Sweden

JUDGING COMMITTEE MEMBER (Ph.D. Dissertation)

  • Ann-Charlotte Andersson (Dec 2014) –  "Characterization of Novel Glomerular Proteins: Role in Physiology and Disease" –  Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Sweden.
  • Stephen Ochaya (March 2013) –  "Comparative genomics and Molecular characterization of N-alpha acetyl transferase in Trypanosomes for drug target identification" – Department of Cell and Molecular Biology, Karolinska Institute, Sweden
  • Lidia Ibáñez Torres (October 2012) – "Involvement of NADPH oxidase and Nrf2/HO-1 pathways in experimental models of arthritis and postmenopausal osteoporosis" –  Department of Pharmacology, University of Valencia, Valencia, Spain

JUDGING COMMITTEE MEMBER (Ph. D. Half-time Control)

  • Katarina Habir (February 2016) – "B cell subsets in autoimmune Disease" – Centre for Molecular Medicine, Karolinska Institute, Sweden.
  • Sevasti Flytzani (February 2013) – "Genetic Regulation of Neuroinflammation" – Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
  • Chengjun Sun (January 2014) – "A study of Biomarker analysis in association with type I diabetes and their shared features in Rheumatoid arthritis" – Department of Medicine, Karolinska Institute, Stockholm, Sweden

EVALUATOR (Ph.D. Dissertation)

  • R. Revathi (Mar 2015) – "Individual and synergetic effects of Umbelliferone with Vitamin C on N-nitrosodiethylamine induced hepatocellular carcinogenesis – an in vivo and in vitro study" – Department of Biochemistry, Periyar University, India.
  • M. Ragunath  (April 2014) – "Molecular mechanisms underlying chemopreventive activities of umbelliferone alone and with 5-flurouracil on 1,2-dimethylhydrazine induced colon carcinogenesis" – Periyar University, India
  • T. Prabu (August 2013) – "Naringin – A flavonone, attenuates liver carcinogenesis by NF-kB mediated apoptotic pathway – in vivo and in vitro studies" – Periyar University, India
  • Pankaj Masih (July 2013) – “Design, Synthesis and hyperglycemic activity of some novel Glitazones” –  JSS University, India

FACULTY OPPONENT

  • Ph.D. Dissertation – Mohammed Mullazehi (May 2009). "Anti-Collagen type II autoantibodies in an acute phenotype of early Rheumatoid arthritis". Department of Oncology, Radiology and Clinical Immunology, Uppsala University, Uppsala, Sweden

GRANT SOURCES

  • Alex and Eva Wallströms
  • AnneGreta Holger Crafoord
  • Department of Medical BIochemistry and Biophysics
  • Greta and Johan Kocks
  • Karolinska Institute (Fobi)
  • Karolinska Institute (KID)
  • Konung Gustaf V:s 80-Years
  • Lund University Diabetic Centre (LUDC)
  • Nanna Svartz
  • Rheumatikerforbundet
  • Swedish Research Council (VR-Medicine)
  • Swedish Research Council (VR-Link)
  • Tore Nilssons
  • Åke Wibergs
  • Österlunds

PATENTS

  • 2010 – Collin M, Allhorn M, Holmdahl R and Nandakumar KS – "Deglycosylated antibodies" – WIPO Patent Application WO/2010/057626
  • 2008 – Blom A, Holmdahl R and Nandakumar KS – "C4bp polypeptides and arthritis"
  • 2006 – Olsson A, Collin M, Bjorck L, Shannon O, holmdahl R and Nandakumar KS – "Therapeutic application of EndoS"
  • 2005 – Bjorck L, Holmdahl R and Nandakumar KS – "IdeS for treatment of IgG antibody mediated diseases and conditions in the areas of autoimmunity, hematology and transplantation" – Patent Number: WO2006131347: Publication Date: 2006-12-14

Nandakumar CV

/ medinflam


Kutty Selva Nandakumar, Ph.D., Dr.Med.Sci.

Associate Professor

Medical Inflammation Research, MBB, Karolinska Institute
Scheeles väg 2 B2, Plan 4, 171 77 Stockholm
Tel: 08-524   86533 (Direct), 0707432769 (mobile),
08-524   87715; 08-524   86337 (lab); Fax: 08-524 87750
e-mail: Nandakumar.Kutty-Selva @ ki.se

EDUCATION

  • Doctor of Medical Science (Dr.Med.Sci.), Immunogenetics – January 2006

Lund University, Medical Inflammation Research, Medical Faculty – Lund, Sweden.  (http://www.med.lu.se/) Supervisor: Prof. Rikard Holmdahl

Thesis: Analysis of effector pathways in arthritis.

  • Doctor of Philosophy (Ph.D.), Immunology – January 1996

Madurai Kamaraj University, Department of Immunology, School of Biological Sciences – Madurai, India. (http://www.mkuniversity.org) Supervisor: Prof. VR. Muthukkaruppan

Thesis: Studies on the importance of porin, an outer membrane protein, in murine and human typhoid.

  • Master of Science (M.Sc.), Biochemistry – April 1988

University of Madras – Department of Biochemistry, PostGraduate Institute of Basic Medical Sciences, Taramani Campus, Chennai, India. (http://www.unom.ac.in)

  • Bachelor of Science (B.Sc.), Chemistry – April 1986

University of Madras – Department of Chemistry, Sacred Heart College, Tiruppattur (http://www.shctpt.edu/)

LAB AND RESEARCH EXPERIENCE

  • Medical Inflammation Research, MBB, Karolinska Institute, Stockholm. Associate Professor. From Dec 2011- (http://www.inflam.mbb.ki.se/)

  • Medical Inflammation Research, MBB, Karolinska Institute, Stockholm. Assistant Professor. From Nov  2008 – Nov 2011 (http://www.inflam.mbb.ki.se/)

  • Medical Inflammation Research, MBB, Karolinska Institute, Stockholm. Research Scientist. From July  2008 – Oct 2008 (http://www.inflam.mbb.ki.se/)

  • Lund University Diabetes Centre/Medical Inflammation Researh (LUDC), Malmo, Sweden. Research Assistant. Identification of genes controlling both inflammation and metabolic syndrome using a heterogeneous stock. From April 2007 – June 2008 (http://www.med.lu.se/ludc)

  • Hansa Medical AB/Medical Inflammation Research (LU), Lund, Sweden. Research Scientist. Theoretical investigation on the use of a bacterial enzyme for treatment in IgG mediated pathologies. February 2007 – March 2007 (http://www.hansamedical.com/)

  • Resistentia Pharmaceuticals AB/Medical Inflammation Research (LU), Uppsala/Lund, Sweden. Research Scientist. Vaccination studies in arthritis. February 2006 – January 2007 (http://www.resistentia.se/)

  • Medical Inflammation Research, Lund University (LU), Lund, Sweden. Postdoctoral Fellow. Development and Characterization of an animal model for arthritis. June 1998 – May 2001 (http://www.med.lu.se)

  • Center for Cellular and Molecular Biology (CCMB), Hyderabad, India. Postdoctoral Fellow. Immune responses to a histiocytic tumor in rats. January 1996 – May 1998 (http://www.ccmb.res.in)

  • Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Project Student. Studies on the role of complement in autoimmune diseases. New Delhi, India. 1988 – 1989 (http://www.aiims.edu)

COMMISSION OF TRUST

Member of the editorial board for the Journals: Current Rheumatology Reviews and Open Rheumatology Journal

Adhoc Referee for the Journals: Arthritis Research Therapy (2004-12),  Scandinavian Journal of Rheumatology (2005), Nature Protocols (2006), European Journal of Immunology (2006-07, 2011), Disease Markers and cancer biomarkers (2007), Biomaterials (2008), Cytokine (2008), BMC Musculoskeletal Disorders (2008), Langmuir (2009), Mediators of Inflammation (2009), Biotechnology Advances (2009) and Scandinavian Journal of Immunology (2010-11).

Evaluation of projects for ARC grant (UK) – 2008, 2010 and 2011.

FIELD OF EXPERTISE

Immunology – Immunogenetics – Inflammation – Rheumatoid Arthritis – Infectious Diseases (Salmonellosis) -Tumor Immunology – Hybridoma – Antibodies – Animal models of human diseases (arthritis, multiple sclerosis and lupus) – Testing vaccines in mice – in vivo experiments

TEACHER TRAINING COURSES

Basic Course on Oral Communication (2002), Lund University; Basic Course in Education for University Teachers (2009), LIME, Karolinska Institute; Postgraduate Supervisor Training Course (2009), LIME, Karolinska Institute; Advanced Course on Communication and Learning (2009), LIME, Karolinska Institute; Teaching International Students (2011), LIME, Karolinska Institute; Web course for Supervisors (2012), LIME, Karolinska Institute.

COURSE ORGANIZER

Multifactorial Immune Mediated Diseases – Etiology and pathogenesis – KI doctoral course – HT 2011

TEACHING EXPERIENCE

(Total hours: 155.45 h teaching + 159 weeks supervision)

Teaching in animal models for human diseases (arthritis, lupus, asthma), immunology and genetics for biomedical students, organic chemistry for undergraduate students and research supervision.

RESEARCH TRAINING – SHORT DURATION

(min period: 2 months during 2002-2010)

M.Sc. students: 3; Ph.D. students: 6; M.D. students: 2; BMA student: 1

FACULTY OPPONENT

Ph.D. Dissertation – Mohammed Mullazehi (May 2009). "Anti-Collagen type II autoantibodies in an acute phenotype of early Rheumatoid arthritis". Department of Oncology, Radiology and Clinical Immunology, Uppsala University, Uppsala, Sweden

GRANTS RECEIVED

Individual Project Grants (year 2007) – Total: 415.000 SEK

Title: "Genetic and Immunologic characterization of antibody-mediated arthritis in mice" and "Identification of genes controlling both inflammation and metabolic syndrome using a heterogeneous stock mice"

Foundations: Alfred Osterlunds, Professor Nanna Svartz, Rheumatikerforbundet, Konung Gustaf V:s 80-Years and Lund University Diabetic Centre (LUDC)


Individual Project Grants (year 2008) – Total: 800.480 SEK

Title: "Studies on genes and pathogenesis of inflammatory diseases"

Foundations: Alfred Osterlunds, Professor Nanna Svartz, Rheumatikerforbundet, Konung Gustaf V:s 80-Years, Greta and Johan Kocks, Alex and Eva Wallstroms and Tore Nilssons


Individual Project Grants (year 2009) – Total: 925.000 SEK

Title: "Studies on genes and pathogenesis of inflammatory diseases"

Foundations: Professor Nanna Svartz, Rheumatikerforbundet, Konung Gustaf V:s 80-Years, Ake Wibergs, Alex and Eva Wallstroms, AnneGreta Holger Crafoord and KI fond (Fobi 2009)


Individual Project Grants (year 2010) – Total: 1217.200 SEK

Title: "IgG mediated Autoimmunity: Fc Glycosylation, Citrulline Recognition and Gene Identification in Arthritis"

Foundations: Ake Wibergs, Professor Nanna Svartz, Reumatikerforbundet, Konung Gustaf V:s 80-Years, Swedish Research Council (VR), Alex and Eva Wallstroms, KI (Fobi 2010)


Individual Project Grants (year 2011) – Total: 944.500 SEK

Title: "IgG mediated Autoimmunity: Fc Glycosylation, Citrulline Recognition and Gene Identification in Arthritis"

Foundations: Konung Gustaf V:s 80-Years, Swedish Research Council (VR), KI (Fobi 2011), Ake Wibergs, Reumatikerforbundet


Individual Project Grants (year 2012) – Total: 350.000 SEK

Title: "IgG mediated Autoimmunity: Fc Glycosylation, Citrulline Recognition and Gene Identification in Arthritis"

Foundations: Swedish Research Council (VR)

COLLABORATION GRANTS

1. Swedish National Collaborative Project Grant (year 2009 – 2014)

Title: "Towards immune specific diagnosis and prevention of rheumatoid arthritis"

(Main applicant: Rikard Holmdahl; Co-applicants: Johan Backlund, Vivi Malmstrom, Kutty Selva Nandakumar and Ronald van Vollenhoven)

VR Collaborative Grant: 12.000.000 SEK

2. International Collaborative Project Grant (years 2009 – 2011)

Title: "Analysis of Host Response to Modified Biocompatible Stimuli-responsive Polymers and Autoantigens Using Murine Experimental arthritis"

Main applicants: Kutty Selva Nandakumar (Sweden) and Ashok Kumar (India)

VR Link Grant: 600.000 SEK

3. Project Grant  (year 2010-2011) – Total: 100.000 SEK

Title: "Smärta och reumatoid artrit: nya angreppspunkter för studier av kronisk värk"

Foundation: Reumatikerforbundet; Main Applicant:  Camilla Svensson, Institutionen för fysiologi och farmakologi, Karolinska Institutet,Co-applicant: Kutty Selva Nandakumar)

INDIVIDUAL GRANT (Nov 2012 – Oct 2015)

Senior Researcher and Continuation grant from Karolinska Institute and MBB.

PATENTS

  1. Bjorck L, Holmdahl R and Nandakumar KS – "IdeS for treatment of IgG antibody mediated diseases and conditions in the areas of autoimmunity, hematology and transplantation" (2005). Patent Number: WO2006131347: Publication Date: 2006-12-14
  2. Olsson A, Collin M, Bjorck L, Shannon O, holmdahl R and Nandakumar KS – "Therapeutic application of EndoS" (2006) 
  3. Blom A, Holmdahl R and Nandakumar KS – "C4bp polypeptides and arthritis" (2008)
  4. Collin M, Allhorn M, Holmdahl R and Nandakumar KS – “Deglycosylated antibodies”  (2010). WIPO Patent Application WO/2010/057626

SUPERVISOR RESPONSIBILITY

  1. Dorota Klaczkowska: Main Supervisor – Ph.D. student in Karolinska Institute from Poland VT 2009 – Dissertation date: 23rd May 2012
  2. Ia Khmaladze: Main Supervisor – Ph.D. student in Karolinska Institute from Georgia – HT 2009 – Current
  3. Ingrid Lindh: Co-Supervisor – Ph.D. student in Karolinska Institute from Sweden – HT 2008 – Current
  4. Gustaf Wigerblad – Co-Supervisor – Ph.D. student in Karolinska Institutet from Sweden – VT 2011 – current

PROFESSIONAL NETWORKS

  1. Linkedin
  2. CERIC

  3. KiiM – Inflammation and Immunology

  4. KI Community

  5. COLL Network
  6. Sasnet