Publications

MIR Publications

/ medinflam

                                                       
                                                       
                                                       

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2016

/ medinflam
  1. Brink M, Hansson M, Mathsson-Alm L, Wijayatunga P, Verheul MK, Trouw LA, Holmdahl R, Rönnelid J, Klareskog L, Rantapää-Dahlqvist S. Rheumatoid factor isotypes in relation to antibodies against citrullinated peptides and carbamylated proteins before the onset of rheumatoid arthritis. Arthritis Res Ther. 2016 Feb 9;18(1):43.
  2. Holmdahl R, Sareila O, Olsson LM, Bäckdahl L, Wing K. Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation. Immunol Rev. 2016 Jan;269(1):228-47. doi: 10.1111/imr.12378. Review.
  3. Shakya AK, Kumar A, Holmdahl R, Nandakumar KS. Macrophage derived reactive oxygen species protects against autoimmune priming with a defined polymeric adjuvant. Immunology. 2016, 147:125-32.

2011

/ medinflam
  1. Hultqvist M, Sareila O, Vilhardt F, Norin U, Olsson LM, Olofsson P, Hellman U, Holmdahl R. Positioning of a Polymorphic Quantitative Trait Nucleotide in the Ncf1 Gene Controlling Oxidative Burst Response and Arthritis Severity in Rats. Antioxid Redox Signal. 2011 Jan 31
  2. Pizzolla A, Gelderman KA, Hultqvist M, Vestberg M, Gustafsson K, Mattsson R, Holmdahl R. CD68-expressing cells can prime T cells and initiate autoimmune arthritis in the absence of reactive oxygen species. Eur J Immunol. 2011 Feb;41(2):403-12
  3. Liu Y, Teige A, Mondoc E, Ibrahim S, Holmdahl R, Issazadeh-Navikas S. Endogenous collagen peptide activation of CD1d-restricted NKT cells ameliorates tissue-specific inflammation in mice. J Clin Invest. 2011 Jan 4;121(1):249-64
  4. Hultqvist, M., Sareila, O., Vilhardt, F., Norin, U., Olsson, L. M., Olofsson, P., Hellman, U. and Holmdahl, R., Positioning of a Polymorphic Quantitative Trait Nucleotide in the Ncf1 Gene Controlling Oxidative Burst Response and Arthritis Severity in Rats. Antioxid Redox Signal 2011;14(12):2373-83
  5. Andersson IE, Andersson CD, Batsalova T, Dzhambazov B, Holmdahl R, Kihlberg J, Linusson, A.. Design of Glycopeptides Used to Investigate Class II MHC Binding and T-Cell Responses Associated with Autoimmune Arthritis. PLoS One. 2011;6(3):e17881
  6. Conigliaro P, Benson R, Patakas A, Kelly SM, Valesini G, Homdahl R, McInnes, I.B. and Garside, P. Characterization of the Anti-Collagen Antibody Response in a new model of chronic polyarthritis Arthritis Rheum. 2011; 2011;63(8):2299-308
  7. Backlund A, Holmdahl M, Mattsson R, Hakansson K, Lindstrom V, Nandakumar KS, et al. Cystatin C influences the autoimmune but not inflammatory response to cartilage type II collagen leading to chronic arthritis development. Arthritis Res Ther. 2011 Mar 28;13(2):R54
  8. Ahlqvist, E., Ekman, D., Lindvall, T., Popovic, M., Förster, M., Hultqvist, M., Klaczkowska, D., I., T., Johannesson, M., Flint, J., Valdar, W., Nandakumar, K. S. and Holmdahl, R., High resolution mapping of a complex disease, a model for rheumatoid arthritis, using heterogeneous stock mice. Hum Mol Genet 2011;20(15):3031-41
  9. Nandakumar KS, Lindqvist A-KB, Holmdahl R. A dominant suppressive MHC class II haplotype interacting with autosomal genes controls autoantibody production and chronicity of arthritis Ann Rheum Dis. 2011; 2011;70(9):1664-70
  10. Kollias G, Papadaki P, Apparailly F, Vervoordeldonk MJ, Holmdahl R, Baumans V, et al. Animal models for Arthritis: Innovative tools for prevention and therapy. Ann Rheum Dis. 2011; 2011;70(8):1357-62
  11. Olsson LM, Nerstedt A, Lindqvist A-K, Johansson Å, Medstrand P, Olofsson P, Holmdahl, R. Copy number variation of the NCF1 gene is associated with Rheumatoid Arthritis Antioxid Redox Signal. 2011;in press
  12. Lindvall T, Nandakumar KS, Yousefi K, Holmdahl R, Andersson A. An encephalomyelitis-specific locus on chromosome 16 in mouse controls disease development and expression of immune-regulatory genes. J Neuroimmunol. 2011;235(1-2):40-7
  13. Zhu W, Meng L, Jiang C, He X, Hou W, Xu P, et al. Arthritis is associated with T-cell-induced upregulation of Toll-like receptor 3 on synovial fibroblasts. Arthritis Res Ther 2011;13(3):R103
  14. Sareila O, Kelkka T, Pizzolla A, Hultqvist M, Holmdahl R. NOX2 Complex-derived ROS as Immune Regulators. Antioxid Redox Signal 2011
  15. Li D, Wang X, Ren W, Ren J, Lan X, Wang F, Li H, Zhang F, han Y, Song T, Holmdahl R, Lu S. High expression of liver histone deacetylase 3 contributes to high-fat-diet-induced metabolic syndrome by suppressing the PPAR-gamma and LXR-alpha-pathways in E3 rats. Mol Cell Endocrinol 2011
  16. Jochems C, Islander U, Erlandsson M, Engdahl C, Lagerquist M, Ohlsson C, Nandakumar KS, Holmdahl R and Carlsten H. Effects of oestradiol and raloxifene on the induction and effector phases of experimental postmenopausal arthritis and secondary osteoporosis. Clin Exp Immunol 2011;165(1):121-9
  17. Croxford AM, Nandakumar KS, Holmdahl R, Tobin MJ, McNaughton D, Rowley MJ. Chemical changes demonstrated in cartilage by synchrotron infrared microspectroscopy in an antibody-induced murine model of rheumatoid arthritis. J Biomed Opt 2011;16(6):066004
  18. Andersson IE, Batsalova T, Haag S, Dzhambazov B, Holmdahl R, Kihlberg J, Linusson, A. (E)-Alkene and Ethylene Isosteres Substantially Alter the Hydrogen-Bonding Network in Class II MHC A(q)/Glycopeptide Complexes and Affect T-Cell Recognition. J Am Chem Soc. 2011 Jul. 18
  19. Cao D, Khmaladze I, Jia H, Bajtner E, Nandakumar KS, Blom T, Mo, JA, Holmdahl, R. Pathogenic autoreactive B cells are not negatively selected toward matrix protein collagen II. J. Immunol. 2011 Nov. 1;187(9):4451–4458
  20. Dobritzsch D, Lindh I, Uysal H, Nandakumar KS, Burkhardt H, Schneider G, Holmdahl R. Crystal structure of an arthritogenic anticollagen immune complex. Arthritis Rheum. 2011 Dec.;63(12):3740–3748
  21. Holmdahl R, Malissen B. The need for littermate controls. Eur. J. Immunol. 2011 Dec. 29;42(1):45–47
  22. Kajsa Wing, Tomoyuki Yamaguchi, Shimon Sakaguchi. Cell-autonomous and nonautonomous roles of CTLA-4 for negative control of immune responses. Trends in Immunology, 2011Sep;32(9):428-33
  23. Shimon Sakaguchi and Kajsa Wing, Immunology. Damping by depletion. Science. 2011 Apr 29;332(6029):542-3
  24. Woodruff TM, Nandakumar KS and Tedesco F (2011). Inhibiting the C5-C5a axis. Mol Immunol 48: 14. 1631-1642. PubMed
  25. Shakya AK, Kumar A and Nandakumar KS (2011). Adjuvant properties of the thermo-responsive polymer of N-isopropylacrylamide in autoimmunity and arthritis.  J R Soc Interface  8:1748-59. PubMed
  26. Klaczkowska D†, Raposo B† and Nandakumar KS (2011). Heterogeneous stock mice are susceptible to encephalomyelitis and antibody initiated arthritis but not collagen and G6PI induced arthritis  Scand J Immunol 73:46-52.   PubMed

2013

/ medinflam
  1. Eneljung T, Tengvall S, Jirholt P, Henningsson L, Holmdahl R, Gustafsson K, Gjertsson I. Antigen-specific gene therapy after immunisation reduces the severity of collagen-induced arthritis. Clin Dev Immunol. 2013;2013:345092. doi: 10.1155/2013/345092. Epub 2013 Nov 26.
  2. Hultqvist M, Olofsson P, Wallner FK, Holmdahl R (2013). Pharmacological potential of  NOX2 agonists in inflammatory conditions. Antioxid Redox Signal. Dec 20. [Epub ahead of print]
  3. Kelkka T, Pizzolla A, Laurila JP, Friman T, Gustafsson R, Källberg E, Olsson O, Leanderson T, Rubin K, Salmi M, Jalkanen S, Holmdahl R. Mice Lacking NCF1 Exhibit Reduced Growth of Implanted Melanoma and Carcinoma Tumors. PLoS One. 2013 8(12):e84148.
  4. Haj Hensvold A, Magnusson PK, Joshua V, Hansson M, Israelsson L, Ferreira R, Jakobsson PJ, Holmdahl R, Hammarstrom L, Malmstrom V, Askling J, Klareskog L, Catrina AI (2013). Environmental and genetic factors in the development of anticitrullinated protein antibodies (ACPAs) and ACPA-positive rheumatoid arthritis: an epidemiological investigation in twins. Ann Rheum Dis. .doi: 10.1136/annrheumdis-2013-203947. [Epub ahead of print] 
  5. Shakya AK, Holmdahl R, Nandakumar KS*, Kumar A*. Polymeric cryogels are biocompatible and their biodegradation is independent of oxidative radicals. J Biomed Mater Res A. 2013 Oct 19. doi: 10.1002/jbm.a.35013. [Epub ahead of print] PubMed PMID: 24142798. *, Shared senior authors.
  6. Pizzolla A, Wing K, Holmdahl R. A Glucose-6-Phosphate Isomerase Peptide Induces T and B Cell-Dependent Chronic Arthritis in C57BL/10 Mice: Arthritis without Reactive Oxidative Species and Complement. Am J Pathol. 2013 Jul 30.doi:pii: S0002-9440(13)00475-6. 10.1016/j.ajpath.2013.06.019.
  7. Geng H, Nandakumar KS, Xiong L, Jie R, Dong J, Holmdahl R. Incomplete B cell tolerance to cartilage oligomeric matrix protein in mice. Arthritis Rheum. 2013 Jun 10. doi: 10.1002/art.38046. [Epub ahead of print]
  8. Shakya AK, Nandakumar KS (2013). Stimuli responsive polymers as adjuvants and carriers for antigen delivery. In: Responsive materials and methods. Edited by: A. Tiwari, H. Kobayashi. 123-140 WILEY-Scrivener, USA
  9. Yamaguchi T, Kishi A, Osaki M, Morikawa H, Prieto-Martin P, Wing K, Saito T, Sakaguchi S. Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression. Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):E2116-25. doi: 10.1073/pnas.1307185110. Epub 2013 May 20.
  10. Rat Genome Sequencing and Mapping Consortium, Baud A, Hermsen R, Guryev V, Stridh P, Graham D, McBride MW, Foroud T, Calderari S, Diez M, Ockinger J, Beyeen AD, Gillett A, Abdelmagid N, Guerreiro-Cacais AO, Jagodic M, Tuncel J, Norin U, Beattie E, Huynh N, Miller WH, Koller DL, Alam I, Falak S, Osborne-Pellegrin M, Martinez-Membrives E, Canete T, Blazquez G, Vicens-Costa E, Mont-Cardona C, Diaz-Moran S, Tobena A, Hummel O, Zelenika D, Saar K, Patone G, Bauerfeind A, Bihoreau MT, Heinig M, Lee YA, Rintisch C, Schulz H, Wheeler DA, Worley KC, Muzny DM, Gibbs RA, Lathrop M, Lansu N, Toonen P, Ruzius FP, de Bruijn E, Hauser H, Adams DJ, Keane T, Atanur SS, Aitman TJ, Flicek P, Malinauskas T, Jones EY, Ekman D, Lopez-Aumatell R, Dominiczak AF, Johannesson M, Holmdahl R, Olsson T, Gauguier D, Hubner N, Fernandez-Teruel A, Cuppen E, Mott R, Flint J. Combined sequence-based and genetic mapping analysis of complex traits in outbred rats. Nat Genet. 2013 May 26. doi: 10.1038/ng.2644. [Epub ahead of print]
  11. Grimm MJ, Vethanayagam RR, Almyroudis NG, Dennis CG, Khan AN, D’Auria AC, Singel KL, Davidson BA, Knight PR, Blackwell TS, Hohl TM, Mansour MK, Vyas JM, Rohm M, Urban CF, Kelkka T, Holmdahl R, Segal BH. Monocyte- and Macrophage-Targeted NADPH Oxidase Mediates Antifungal Host Defense and Regulation of Acute Inflammation in Mice. J Immunol. 2013 190(8):4175-84.
  12. Shakya AK, Holmdahl R, Nandakumar KS*, Kumar A*. Characterization of chemically defined poly-N-isopropylacrylamide based copolymeric adjuvants. Vaccine. 2013 Jun 3. doi:pii: S0264-410X(13)00699-3. 10.1016/j.vaccine.2013.05.084. [Epub ahead ofprint]. *, Shared senior authors.
  13. Sareila O, Jaakkola N, Olofsson P, Kelkka T, Holmdahl R. Identification of a region in p47phox/NCF1 crucial for phagocytic NADPH oxidase (NOX2) activation. J Leukoc Biol. 2013 93:427-35.
  14. Croxford AM, Whittingham S, McNaughton D, Nandakumar KS, Holmdahl R, Rowley MJ. Type II collagen-specific antibodies induce cartilage damage in mice independent of inflammation. Arthritis Rheum. 2013 65:650-9.
  15. Shakya AK, Nandakumar KS. Applications of polymeric adjuvants in studying autoimmune responses and vaccination against infectious diseases. J R Soc Interface. 2013 10(79):20120536.
  16. Colaianna M, Schiavone S, Zotti M, Tucci P, Morgese MG, Backdahl L, Holmdahl R, Krause KH, Cuomo V, Trabace L. Neuroendocrine profile in a rat model of psychosocial stress: relation to oxidative stress. Antioxid Redox Signal. 2013 18(12):1385-99.
  17. Brink M, Hansson M, Mathsson L, Jakobsson PJ, Holmdahl R, Hallmans G, Stenlund H, Ronnelid J, Klareskog L, Dahlqvist SR. Multiplex analyses of antibodies against citrullinated peptides in individuals prior to development of rheumatoid arthritis. Arthritis Rheum. 2013 65(4):899-910.

2010

/ medinflam
  1. Uysal, H., K.S. Nandakumar, C. Kessel, S. Haag, S. Carlsen, H. Burkhardt, and R. Holmdahl. 2010. Antibodies to citrullinated proteins: molecular interactions and arthritogenicity. Immunological Reviews, Vol. 233: 9–33. Pubmed
  2. Wing, K and Sakaguchi, S. Regulatory T cells exert checks and balances on self-tolerance and autoimmunity. Nature Immunology, 2010 Jan;11(1):7-13. Pubmed
  3. Hultqvist M, Nandakumar KS, Björklund U and Holmdahl R (2010). Rebeximod reduces arthritis severity in mice by decreasing macrophage activation. Ann Rheum Dis, 2010 Aug;69(8):1527-32. Pubmed
  4. Nandakumar KS (2010). Pathogenic antibody recognition of cartilage. Cell and Tissue Res 339:213-220. Pubmed
  5. Van de Velde, N. C., P. L. Mottram, M. S. Powell, B. Lim, R. Holmdahl, and P. M. Hogarth. Transgenic mice expressing human FcgammaRIIa have enhanced sensitivity to induced autoimmune arthritis as well as elevated Th17 cells. Immunol Lett 130, 82-8 (2010). Pubmed
  6. Snir, O., M. Widhe, M. Hermansson, C. von Spee, J. Lindberg, S. Hensen, K. Lundberg, A. Engstrom, P. J. Venables, R. E. Toes, R. Holmdahl, L. Klareskog, and V. Malmstrom. 2010. Antibodies to several citrullinated antigens are enriched in the joints of rheumatoid arthritis patients. Arthritis Rheum 62:44-52. Pubmed
  7. Rintisch, C., T. Kelkka, U. Norin, J. C. Lorentzen, P. Olofsson, and R. Holmdahl. 2010. Finemapping of the arthritis QTL Pia7 reveals co-localization with Oia2 and the APLEC locus. Genes Immun Genes Immun 11, 239-45 (2010). Pubmed
  8. Andersson, I., T. Batsalova, B. Dzhambazov, L. Edvinsson, R. Holmdahl, J. Kihlberg, and A. Linusson. 2010. Oxazole glycopeptidomimetics that target arthritisassociated class II MHC Aq and DR4 proteins. Organic & Biomolecular Chemistry in press. Pubmed
  9. Sareila, O., Kelkka, T., Hultqvist, M., Pizzolla, A. & Holmdahl, R. NOX2-derived ROS as immune regulators. Antioxidants & Redox Signaling. In press. (2010). Pubmed
  10. Meng L, Zhu W, Jiang C, He X, Hou W, Zheng F, Holmdahl R, Lu S:  Toll-like receptor 3 upregulation in macrophages participates in the initiation and maintenance of pristane-induced arthritis in rats. Arthritis Res Ther 12, R103 (2010).
  11. Batsalova T, Dzhambazov B, Merky P, Bäcklund A, Bäcklund J. Breaking T cell tolerance against self type II collagen in HLA-DR4-transgenic mice and development of autoimmune arthritis. Arthritis Rheum. 2010 Jul;62(7):1911-20. Pubmed
  12. Hultqvist, M., Nandakumar, K.S., Björklund, U. & Holmdahl, R. The small compound Rabeximod reduces arthritis severity in mice by decreasing macrophage activation Ann Rheum Dis. 2010 Aug;69(8):1527-32
  13. Gillett A, Marta M, Jin T, Tuncel J, Leclerc P, Nohra R, Holmdahl R, Olsson T, Jagodic M: TNF Production in Macrophages Is Genetically Determined and Regulates Inflammatory Disease in Rats. J Immunol in press(2010).
  14. Croxford AM, Crombie D, McNaughton D, Holmdahl R, Nandakumar KS, Rowley MJ: Specific antibody protection of the extracellular cartilage matrix against collagen antibody-induced damage. Arthritis Rheum in press(2010).
  15. Batsalova, T., Dzhambazov, B., Klaczkowska, D. & Holmdahl, R. Mice producing less reactive oxygen species are relatively resistant to collagen glycopeptide vaccination against arthritis J Immunol in press(2010).
  16. Holmdahl, R., At last; Rats lacking B cell. Eur J Immunol 2010. in press
  17. Merky P, Batsalova T, Bockermann R, Dzhambazov B, Sehnert B, Burkhardt H, Bäcklund J. Visualization and phenotyping of proinflammatory antigen-specific T cells during collagen-induced arthritis in a mouse with a fixed collagen type II-specific transgenic T-cell receptor β-chain. Arthritis Res Ther. 2010;12(4):R155. Pubmed
  18. Jochems C, Islander U, Erlandsson M, Engdahl C, Lagerquist M, Gjertsson I, Ohlsson C, Holmdahl R, Carlsen H. Role of endogenous and exogenous female sex hormones in arthritis and osteoporosis development in B10.Q-ncf1*/* mice with collagen-induced arthritis. BMC Musculoskelet Disord 2010 Dec 16;11:284.
  19. Nandakumar KS, Jansson A, Xu B, Rydell N, Blom AM, Holmdahl R. A recombinant vaccine effectively induces c5a-specific neutralizing antibodies and prevents arthritis. PLoS One. 2010 Oct 20;5(10):e13511.

2007

/ medinflam
  1. von Delwig A, Altmann DM, Charlton FG, McKie N, Isaacs JD, Holmdahl R, Robinson JH. 2007. T cell responses to a non-glycosylated epitope predominate in type II collagen-immunised HLA-DRB1*0101 transgenic mice. Ann Rheum Dis 66: 599-604
  2. Olsson LM, Lindqvist AK, Kallberg H, Padyukov L, Burkhardt H, Alfredsson L, Klareskog L, Holmdahl R. 2007. A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity. Arthritis Res Ther 9: R98
  3. Olofsson P, Nerstedt A, Hultqvist M, Nilsson EC, Andersson S, Bergelin A, Holmdahl R. 2007. Arthritis suppression by NADPH activation operates through an interferon-beta pathway. BMC Biol 5: 19
  4. Olofsson P, Holmdahl R. 2007. Pristane-induced arthritis in the rat. Methods Mol Med 136: 255-68
  5. Okroj M, Heinegard D, Holmdahl R, Blom AM. 2007. Rheumatoid arthritis and the complement system. Ann Med 39: 517-30
  6. Nilsang S, Nandakumar KS, Galaev IY, Rakshit SK, Holmdahl R, Mattiasson B, Kumar A. 2007. Monoclonal antibody production using a new supermacroporous cryogel bioreactor. Biotechnol Prog 23: 932-9
  7. Nandakumar KS, Johansson BP, Bjorck L, Holmdahl R. 2007. Blocking of experimental arthritis by cleavage of IgG antibodies in vivo. Arthritis Rheum 56: 3253-60
  8. Nandakumar KS, Holmdahl R. 2007. Collagen antibody induced arthritis. Methods Mol Med 136: 215-23
  9. Nandakumar KS, Collin M, Olsen A, Nimmerjahn F, Blom AM, Ravetch JV, Holmdahl R. 2007. Endoglycosidase treatment abrogates IgG arthritogenicity: importance of IgG glycosylation in arthritis. Eur J Immunol 37: 2973-82
  10. Laurie KL, Blundell MP, Baxendale HE, Howe SJ, Sinclair J, Qasim W, Brunsberg U, Thrasher AJ, Holmdahl R, Gustafsson K. 2007. Cell-specific and efficient expression in mouse and human B cells by a novel hybrid immunoglobulin promoter in a lentiviral vector. Gene Ther 14: 1623-31
  11. Jonsson IM, Verdrengh M, Brisslert M, Lindblad S, Bokarewa M, Islander U, Carlsten H, Ohlsson C, Nandakumar KS, Holmdahl R, Tarkowski A. 2007. Ethanol prevents development of destructive arthritis. Proc Natl Acad Sci U S A 104: 258-63
  12. Hultqvist M, Backlund J, Bauer K, Gelderman KA, Holmdahl R. 2007. Lack of reactive oxygen species breaks T cell tolerance to collagen type II and allows development of arthritis in mice. J Immunol 179: 1431-7
  13. Holmdahl R. 2007. Primer: comparative genetics of animal models of arthritis–a tool to resolve complexity. Nat Clin Pract Rheumatol 3: 104-11
  14. Holmdahl R. 2007. Aire-ing self antigen variability and tolerance. Eur J Immunol 37: 598-601
  15. Holmdahl R. 2007. The use of animal models for rheumatoid arthritis. Methods Mol Med 136: 185-9
  16. Holm L, Frech K, Dzhambazov B, Holmdahl R, Kihlberg J, Linusson A. 2007. Quantitative structure-activity relationship of peptides binding to the class II major histocompatibility complex molecule Aq associated with autoimmune arthritis. J Med Chem 50: 2049-59
  17. Hoffmann MH, Tuncel J, Skriner K, Tohidast-Akrad M, Turk B, Pinol-Roma S, Serre G, Schett G, Smolen JS, Holmdahl R, Steiner G. 2007. The rheumatoid arthritis-associated autoantigen hnRNP-A2 (RA33) is a major stimulator of autoimmunity in rats with pristane-induced arthritis. J Immunol 179: 7568-76
  18. Hjelmervik TO, Lindqvist AK, Petersen K, Johannesson M, Stavrum AK, Johansson A, Jonsson R, Holmdahl R, Bolstad AI. 2007. The influence of the NOD Nss1/Idd5 loci on sialadenitis and gene expression in salivary glands of congenic mice. Arthritis Res Ther 9: R99
  19. Gelderman KA, Hultqvist M, Pizzolla A, Zhao M, Nandakumar KS, Mattsson R, Holmdahl R. 2007. Macrophages suppress T cell responses and arthritis development in mice by producing reactive oxygen species. J Clin Invest 117: 3020-8
  20. Gelderman KA, Hultqvist M, Olsson LM, Bauer K, Pizzolla A, Olofsson P, Holmdahl R. 2007. Rheumatoid arthritis: the role of reactive oxygen species in disease development and therapeutic strategies. Antioxid Redox Signal 9: 1541-67
  21. Carlsen S, Lu S, Holmdahl R. 2007. Arthritis induced with minor cartilage proteins. Methods Mol Med 136: 225-42
  22. Bockermann R, Holmdahl R. 2007. Type II collagen without adjuvant induces eosinophilic arthritis. Eur J Immunol 37: 540-8
  23. Andersson IE, Dzhambazov B, Holmdahl R, Linusson A, Kihlberg J. 2007. Probing molecular interactions within class II MHC Aq/glycopeptide/T-cell receptor complexes associated with collagen-induced arthritis. J Med Chem 50: 5627-43
  24. Ahlqvist E, Bockermann R, Holmdahl R. 2007. Fragmentation of two quantitative trait loci controlling collagen-induced arthritis reveals a new set of interacting subloci. J Immunol 178: 3084-90

1995

/ medinflam
  1. Zhao YX, Abdelnour A, Holmdahl R, Tarkowski A. 1995. Mice with the xid B cell defect are less susceptible to developing Staphylococcus aureus-induced arthritis. J Immunol 155: 2067-76
  2. Vingsbo C, Jonsson R, Holmdahl R. 1995. Avridine-induced arthritis in rats; a T cell-dependent chronic disease influenced both by MHC genes and by non-MHC genes. Clin Exp Immunol 99: 359-63
  3. Verdrengh M, Holmdahl R, Tarkowski A. 1995. Administration of antibodies to hyaluronanreceptor (CD44) delays the start and ameliorates the severity of collagen II arthritis. Scand J Immunol 42: 353-8
  4. Sundvall M, Jirholt J, Yang HT, Jansson L, Engstrom A, Pettersson U, Holmdahl R. 1995. Identification of murine loci associated with susceptibility to chronic experimental autoimmune encephalomyelitis. Nat Genet 10: 313-7
  5. Skarstein K, Holmdahl R, Johannessen AC, Goldschmidt T, Jonsson R. 1995. Short-term administration of selected anti-T-cell receptor V beta chain specific MoAb reduces sialadenitis in MRL/lpr mice. Scand J Immunol 42: 529-34
  6. Michaelsson E, Holmdahl M, Engstrom A, Burkhardt H, Scheynius A, Holmdahl R. 1995. Macrophages, but not dendritic cells, present collagen to T cells. Eur J Immunol 25: 2234-41
  7. Karlsson R, Mo JA, Holmdahl R. 1995. Binding of autoreactive mouse anti-type II collagen antibodies derived from the primary and the secondary immune response investigated with the biosensor technique. J Immunol Methods 188: 63-71
  8. Jansson L, Diener P, Engstrom A, Olsson T, Holmdahl R. 1995. Spreading of the immune response to different myelin basic protein peptides in chronic experimental autoimmune encephalomyelitis in B10.RIII mice. Eur J Immunol 25: 2195-200
  9. Holmdahl R, Vingsbo C, Mo JA, Michaelsson E, Malmstrom V, Jansson L, Brunsberg U. 1995. Chronicity of tissue-specific experimental autoimmune disease: a role for B cells? Immunol Rev 144: 109-35
  10. Holmdahl R. 1995. Female preponderance for development of arthritis in rats is influenced by both sex chromosomes and sex steroids. Scand J Immunol 42: 104-9
  11. Hjulstrom S, Landin A, Jansson L, Holmdahl R, Heyman B. 1995. No role of interleukin-4 in CD23/IgE-mediated enhancement of the murine antibody response in vivo. Eur J Immunol 25: 1469-72

 

2008

/ medinflam
  1. Wang H, Kess D, Lindqvist AK, Peters T, Sindrilaru A, Wlaschek M, Blakytny R, Holmdahl R, Scharffetter-Kochanek K. 2008. A 9-centimorgan interval of chromosome 10 controls the T cell-dependent psoriasiform skin disease and arthritis in a murine psoriasis model. J Immunol 180: 5520-9. PubMed
  2. Uysal H, Sehnert B, Nandakumar KS, Boiers U, Burkhardt H, Holmdahl R, Thunnissen MM. 2008. The crystal structure of the pathogenic collagen type II-specific mouse monoclonal antibody CIIC1 Fab: structure to function analysis. Mol Immunol 45: 2196-204. PubMed
  3. Snir O, Widhe M, von Spee C, Lindberg J, Padyukov L, Lundberg K, Engstrom A, Venables PJ, Lundeberg J, Holmdahl R, Klareskog L, Malmstrom V. 2008. Multiple antibody reactivities to citrullinated antigens in sera from rheumatoid arthritis patients – association with HLA-DRB1 alleles. Ann Rheum Dis 68: 736-43.. PubMed
  4. Rowley MJ, Nandakumar KS, Holmdahl R. 2008. The role of collagen antibodies in mediating arthritis. Mod Rheumatol. 18: 429-41. PubMed
  5. Rintisch C, Holmdahl R. 2008. DA rats from two colonies differ genetically and in their arthritis susceptibility. Mamm Genome 19: 420-8. PubMed
  6. Nandakumar KS, Holmdahl R. 2008. Therapeutic cleavage of IgG: new avenues for treating inflammation. Trends Immunol 29: 173-8. PubMed
  7. Nandakumar KS, Holmdahl R. 2008. Role of anti-hinge antibodies in therapeutic cleavage of IgG: response to Drs. Lutz and Fumia. Trends Immunol 29: 355-6. PubMed
  8. Nandakumar KS, Bajtner E, Hill L, Bohm B, Rowley MJ, Burkhardt H, Holmdahl R. 2008. Arthritogenic antibodies specific for a major type II collagen triple-helical epitope bind and destabilize cartilage independent of inflammation. Arthritis Rheum 58: 184-96. PubMed
  9. Liljander M, Andersson A, Holmdahl R, Mattsson R. 2008. Increased susceptibility to collagen-induced arthritis in female mice carrying congenic Cia40/Pregq2 fragments. Arthritis Res Ther 10: R88. PubMed
  10. Lagerquist MK, Erlandsson MC, Islander U, Svensson L, Holmdahl R, Carlsten H. 2008. 17Beta-estradiol expands IgA-producing B cells in mice deficient for the mu chain. Scand J Immunol 67: 12-7. PubMed
  11. Imai Y, Kuba K, Neely GG, Yaghubian-Malhami R, Perkmann T, van Loo G, Ermolaeva M, Veldhuizen R, Leung YH, Wang H, Liu H, Sun Y, Pasparakis M, Kopf M, Mech C, Bavari S, Peiris JS, Slutsky AS, Akira S, Hultqvist M, Holmdahl R, Nicholls J, Jiang C, Binder CJ, Penninger JM. 2008. Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell 133: 235-49. PubMed
  12. Hultqvist M, Nandakumar KS, Bjorklund U, Holmdahl R. 2008. The novel small molecule drug Rabeximod is effective in reducing disease severity of mouse models of autoimmune disorders. Ann Rheum Dis 68: 130-5. PubMed
  13. Holmdahl R. 2008. IL-21 and autoimmune disease–hypothesis and reality? Eur J Immunol 38: 1800-2. PubMed
  14. Holmdahl M, Ahlfors SR, Holmdahl R, Hansson C. 2008. Structure-Immune Response Relationships of Hapten-Modified Collagen II Peptides in a T-Cell Model of Allergic Contact Dermatitis. Chem Res Toxicol 21: 1514-23. PubMed
  15. Carlsen S, Nandakumar KS, Backlund J, Holmberg J, Hultqvist M, Vestberg M, Holmdahl R. 2008. Cartilage oligomeric matrix protein induction of chronic arthritis in mice. Arthritis Rheum 58: 2000-11. PubMed
  16. Blom AM, Nandakumar KS, Holmdahl R. 2008. C4b-binding protein (C4BP) inhibits development of experimental arthritis in mice. Ann Rheum Dis 68: 136-42. PubMed
  17. Aitman TJ, Critser JK, Cuppen E, Dominiczak A, Fernandez-Suarez XM, Flint J, Gauguier D, Geurts AM, Gould M, Harris PC, Holmdahl R, Hubner N, Izsvak Z, Jacob HJ, Kuramoto T, Kwitek AE, Marrone A, Mashimo T, Moreno C, Mullins J, Mullins L, Olsson T, Pravenec M, Riley L, Saar K, Serikawa T, Shull JD, Szpirer C, Twigger SN, Voigt B, Worley K. 2008. Progress and prospects in rat genetics: a community view. Nat Genet 40: 516-22. PubMed
  18. Boiers U, Lanig H, Sehnert B, Holmdahl R, and Burkhardt H. 2008. Collagen type II is recognized by a pathogenic antibody through germline encoded structures. Eur J Immunol 38:2784-95. PubMed
  19. Johannesson M, Lopez-Aumatell R, Diez M, Tuncel J, Blazquez G, Martinez E, Canete A, Vicens-Costa E, Graham D, Copley R, Hernandez-Pliego P, Beyeen A, Stridh P, Ockinger J, Fernandez C, Gulko PS, Brenner M, Tobena A, Guitart-Masip M, Gimenez-Llort L, Dominiczak A, Holmdahl R, Gauguier D, Olsson T, Mott R, Valdar W, Redei E, Fernandez-Teruel A, and Flint J. 2008. A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: The NIH heterogeneous stock. Genome Res 19: 150-8. PubMed
  20. Popovic M, Ahlqvist E, Rockenbauer E, Bockermann R, and Holmdahl R. 2008. Identification of new loci controlling collagen-induced arthritis in mouse using a partial advanced intercross and congenic strains. Scand J Immunol 68: 405-13. PubMed
  21. Rintisch C, Ameri J, Olofsson P, Luthman H, and Holmdahl R. 2008. Positional cloning of the Igl genes controlling rheumatoid factor production and allergic bronchitis in rats. Proc Natl Acad Sci U S A 105: 14005-10. PubMed
  22. Geng, H., Carlsen, S., Nandakumar, K. S., Holmdahl, R., Aspberg, A., Oldberg, A., and Mattsson, R. 2008. Cartilage oligomeric matrix protein deficiency promotes early onset and the chronic development of collagen-induced arthritis. Arthritis Res Ther 10: R134. PubMed
  23. Nilsang, S., Nehru, V., Plieva, F. M., Nandakumar, K. S., Rakshit, S. K., Holmdahl, R., Mattiasson, B., and Kumar, A. 2008. Three-dimensional culture for monoclonal antibody production by hybridoma cells immobilized in macroporous gel particles. Biotechnol Prog 24: 1122-31. PubMed
  24. Eklow, C., Makrygiannakis, D., Backdahl, L., Padyukov, L., Ulfgren, A. K., Lorentzen, J. C., and Malmstrom, V. 2008. Cellular distribution of the C-type II lectin dendritic cell immunoreceptor (DCIR) and its expression in the rheumatic joint: identification of a subpopulation of DCIR+ T cells. Ann Rheum Dis 67: 1742-9. PubMed
  25. Guo, J. P., Backdahl, L., Marta, M., Mathsson, L., Ronnelid, J., and Lorentzen, J. C. 2008. Profound and paradoxical impact on arthritis and autoimmunity of the rat antigen-presenting lectin-like receptor complex. Arthritis Rheum 58: 1343-53. PubMed
  26. Ronninger, M., Eklow, C., Lorentzen, J. C., Klareskog, L., and Padyukov, L. 2008. Differential expression of transcripts for the autoimmunity-related human dendritic cell immunoreceptor. Genes Immun 9: 412-8. PubMed
  27. Backdahl, L., Guo, J. P., Jagodic, M., Becanovic, K., Ding, B., Olsson, T., and Lorentzen, J. C. 2008. Definition of arthritis candidate risk genes by combining rat linkage-mapping results with human case control association data. Ann Rheum Dis. PubMed

 

1984

/ medinflam
  1. Svenson KL, Holmdahl R, Klareskog L, Wibell L, Sjoberg O, Klintmalm GB, Bostrom H. 1984. Cyclosporin A treatment in a case of relapsing polychondritis. Scand J Rheumatol 13: 329-33
  2. Rubin K, Borg TK, Holmdahl R, Klareskog L, Obrink B. 1984. Interactions of mammalian cells with collagen. Ciba Found Symp 108: 93-116
  3. Olsson T, Holmdahl R, Klareskog L, Forsum U, Kristensson K. 1984. Dynamics of Ia-expressing cells and T lymphocytes of different subsets during experimental allergic neuritis in Lewis rats. J Neurol Sci 66: 141-9

 

1992

/ medinflam
  1. Persson S, Post C, Holmdahl R, Nyberg F. 1992. Decreased neuropeptide-converting enzyme activities in cerebrospinal fluid during acute but not chronic phases of collagen induced arthritis in rats. Brain Res 581: 273-82
  2. Nordling C, Karlsson-Parra A, Jansson L, Holmdahl R, Klareskog L. 1992. Characterization of a spontaneously occurring arthritis in male DBA/1 mice. Arthritis Rheum 35: 717-22
  3. Michaelsson E, Andersson M, Engstrom A, Holmdahl R. 1992. Identification of an immunodominant type-II collagen peptide recognized by T cells in H-2q mice: self tolerance at the level of determinant selection. Eur J Immunol 22: 1819-25
  4. Mbacham WF, Titanji VP, Thunberg L, Holmdahl R, Rubin K. 1992. A monoclonal antibody-based immunodiagnostic assay for onchocerciasis. Trop Med Parasitol 43: 83-90
  5. Mattsson R, Mattsson A, Holmdahl R, Scheynius A, Van der Meide PH. 1992. In vivo treatment with interferon-gamma during early pregnancy in mice induces strong expression of major histocompatibility complex class I and II molecules in uterus and decidua but not in extra-embryonic tissues. Biol Reprod 46: 1176-86
  6. Mattsson R, Mattsson A, Hansson I, Holmdahl R, Rook GA, Whyte A. 1992. Increased levels of prolactin during, but not after, the immunisation with rat collagen II enhances the course of arthritis in DBA/1 mice. Autoimmunity 11: 163-70
  7. Jansson L, Holmdahl R. 1992. Oestrogen-induced suppression of collagen arthritis; 17 beta-oestradiol is therapeutically active in normal and castrated F1 hybrid mice of both sexes. Clin Exp Immunol 89: 446-51
  8. Holmdahl R, Vingsbo C, Hedrich H, Karlsson M, Kvick C, Goldschmidt TJ, Gustafsson K. 1992. Homologous collagen-induced arthritis in rats and mice are associated with structurally different major histocompatibility complex DQ-like molecules. Eur J Immunol 22: 419-24
  9. Holmdahl R, Kvick C. 1992. Vaccination and genetic experiments demonstrate that adjuvant-oil-induced arthritis and homologous type II collagen-induced arthritis in the same rat strain are different diseases. Clin Exp Immunol 88: 96-100
  10. Holmdahl R, Jansson L, Andersson M, Jonsson R. 1992. Genetic, hormonal and behavioural influence on spontaneously developing arthritis in normal mice. Clin Exp Immunol 88: 467-72
  11. Holmdahl R, Goldschmidt TJ, Kleinau S, Kvick C, Jonsson R. 1992. Arthritis induced in rats with adjuvant oil is a genetically restricted, alpha beta T-cell dependent autoimmune disease. Immunology 76: 197-202
  12. Hansson I, Holmdahl R, Mattsson R. 1992. The pineal hormone melatonin exaggerates development of collagen-induced arthritis in mice. J Neuroimmunol 39: 23-30
  13. Goldschmidt TJ, Andersson M, Malmstrom V, Holmdahl R. 1992. Activated type II collagen reactive T cells are not eliminated by in vivo anti-CD4 treatment. Implications for therapeutic approaches on autoimmune arthritis. Immunobiology 184: 359-71
  14. Carlsten H, Nilsson N, Jonsson R, Backman K, Holmdahl R, Tarkowski A. 1992. Estrogen accelerates immune complex glomerulonephritis but ameliorates T cell-mediated vasculitis and sialadenitis in autoimmune MRL lpr/lpr mice. Cell Immunol 144: 190-202
  15. Cabero JL, Sasaki T, Song YH, Holmdahl R, Mardh S. 1992. Production of monoclonal antibodies against gastric parietal cell antigens. Acta Physiol Scand 144: 369-78
  16. Burkhardt H, Yan T, Broker B, Beck-Sickinger A, Holmdahl R, Von der Mark K, Emmrich F. 1992. Antibody binding to a collagen type-II epitope gives rise to an inhibitory peptide for autoreactive T cells. Eur J Immunol 22: 1063-7
  17. Andersson M, Jansson L, Holmdahl R. 1992. Role for T-cell receptor Vb genes in collagen induced arthritis. Immunogenetics 35: 71-2; author reply 3-4