Rikard Holmdahl

Rikard Holmdahl

/ medinflam

Rikard Holmdahl

Research in the Holmdahl group:

To obtain basic biological knowledge explaining the development of chronic inflammatory disorders (CID), such as rheumatoid arthritis and multiple sclerosis, we use experimental animal models. The goal is to identify prognostic markers and to establish new therapies for these diseases. During the next period we have the following more specific goals:

1) To identify new pathways that control pathogenic inflammation using an experimental animal platform.

2) To translate the identification of selected genes associated with human CID to the animal model platform and the knowledge of new selected pathways in the animal models to human CID’s.

3) To understand the role of MHC class II genes in explaining the immune specificity of autoimmune disease and to develop a new type of vaccination strategy for treatment of rheumatoid arthritis

4) To understand the new Ncf1 controlled oxygen burst pathway associated with severe inflammation and to develop a new type of anti-inflammatory treatment based on oxidants.

CV

Awarded PhD Students

/ medinflam

I. Awarded PhD Students (Rikard Holmdahl)


Main supervision:

  1. Mikael Andersson: 901214, "Self reactivity and tolerance in the immune system. Studies on T cells in murine type II collagen-induced arthritis", Medical Faculty, Uppsala University, opponent Antonio Coutinho, Paris.
  2. Tom J Goldschmidt: 910927, “T lymphocytes in autoimmune arthritis. Monoclonal antibody treatments in mouse and rat”, Medical Faculty, Uppsala University, opponent Anne Cooke, Cambridge.
  3. Liselotte Jansson, 940330; “Sex mediated influence in experimental models for rheumatoid arthritis and multiple sclerosis” Medical Faculty, Uppsala University, opponent Paul Wooley, Detroit.
  4. John A Mo, 941007; “B cell recognition of type II collagen in mouse cartilage” Medical Faculty, Uppsala University opponent Dan Holmberg, Umeå.
  5. Erik Michaëlsson, 960404, “T cell recognition of type II collagen – A cartilage glycoprotein of importance for autoimmune arthritis”, Medical Faculty, Lund University, opponent Polly Matzinger, New York.
  6. Vivianne Malmström, 970920, “Arthritis susceptibility and tolerance in collagen transgenic mice”, Medical Faculty, Lund University, opponent Erna Möller, Stockholm.
  7. Carina Vingsbo-Lundberg, 971108, “Chronic autoimmune arthritis in rats; pathogenesis and genetic factors”, Medical Faculty, Lund University, opponent Frank Emmrich, Leipzig.
  8. Ulrica Brunsberg, 980516, "The importance of major histocompatibility complex class II genes for the development of autoimmune inflammation", Medical Faculty, Lund University, opponent Ulf Gyllensten, Uppsala.
  9. Peter Kjellén, 991201, "The structural basis of MHC control in experimental autoimmunity", Medical Faculty, Lund University, opponent Sören Buus, Copenhagen.
  10. Alexandre Corthay, 000310, “T cells in autoimmunity, studies on murine type II collagen induced arthritis”, Medical faculty, Lund University, opponent George Kollias, Athens.
  11. Johan Jirholt, 001215, “A search for genes influencing autoimmunity. Focus on rheumatoid arthritis and multiple sclerosis”, Medical faculty, Lund University, opponent Holger Luthman, Stockholm.
  12. Mikael Vestberg, 010126, “MHC and transgenic mice. A study into function and polymorphism of class I and class II molecules”, Medical faculty, Lund University, opponent Jan Böhme, Stockholm.
  13. Ann-Sofie Hansson, 011019, “New models for relapsing polychondritis and rheumatoid arthritis, focus on the tissue specifc response”, Medical faculty, Lund University, opponent Norman Staines, London.
  14. Åsa Johansson, 011019, “T cells, cytokines, and genetic factors in autoimmunity. Studies of experimental models of arthritis and sialadenitis”, Medical faculty, Lund University, opponent Linda Wicker, Cambridge.
  15. Shemin Lu, 020212, “Genetic analyses and vaccination of rat models of arthritis”, Medical faculty, Lund University, opponent Raimund Kinne, Jena.
  16. Lars Svensson, 020213, “Role of B cells and cytokines in arthritis”, Medical faculty, Lund University, opponent Hans Carlsten, Göteborg.
  17. Johan Bäcklund, 020924, “Studies on T cells reactive with posttranslational modifcation in arthritis”, Medical faculty, Lund University, opponent Ludvig Sollid, Oslo.
  18. Patrik Wernhoff, 020924, “Genetic control of autoantibodies in experimental autoimmune disease”, Medical faculty, Lund University, opponent Claudia Berek, Berlin.
  19. Peter Olofsson, 030527, “Identification of arthritis regulating genes in rats”Medical faculty, Lund University, opponent Tim Aitman, London.
  20. Jens Holmberg, 041210, “Reduced ROS production triggers arthritis”Medical faculty, Lund University, opponent Cor Verweij, Amsterdam.
  21. Martina Johannesson, 050128, “Novel strategies to explore the complex genetics of autoimmune diseases”Medical faculty, Lund University, opponent Karl Broman, Baltimore, USA.
  22. Robert Bockermann, 050523 “The role of T cells and T cell receptor polymolrphism in controlling pathways leading to arthritis”Medical faculty, Lund University, opponent Juan Lafaille, New York, USA.
  23. Estelle Bajtner, 050917, “Role of collagen type II specific antibodies in arthritis”. Medical faculty, Lund University, opponent Marie Wahren, KI, Stockholm.
  24. Stefan Carlsen, 051015, “Cartilage proteins and their antigenic properties in arthritis”, Medical faculty, Lund University, opponent Richard Williams, London, UK.
  25. Kutty Selva Nandakumar, 060127, “Analysis of effector pathways in arthritis”, Medical faculty, Lund University, opponent Birgitta Heyman, Uppsala, Sweden
  26. Lina Olsson, 071130, “Genetic and genomic analysis of arthritis regulating regions in human and mouse.” Medical faculty, Lund University, opponent Janna Saarela, National Public Health Institute, Helsinki, Finland.
  27. Emma Ahlqvist, 071201, “Identification of arthritis susceptibility genes in mice and humans” Medical faculty, Lund University, opponent Jonathan Flint, Oxford University, Oxford, UK.
  28. Malin Hultqvist, 071214, “The role of reactive oxygen species in animal models of autoimmunity” Medical faculty, Lund University, opponent Philip Hawkins, The Babraham Institute, Cambridge, UK.
  29. Carola Rintisch, 090213, "From Disease to the Gene-identification of arthritis-regulating loci in rats" Medical faculty, Lund University, opponent Abdelhadi Saoudi, National Institute of Health and Medical Research, University Paul Sabatier, Hospital Purpan, Toulouse, France
  30. Therese Lindvall, 091127, "From Disease to Genes in Animal Models of Rheumatoid Arthritis and Multiple Sclerosis" Medical faculty, Lund University, opponent Krisitna Lejon, Immunology, Umeå University
  31. Angela Pizzolla, 111209, "The role of Macrophages in Regulating Inflammation by Oxidative Burst". Karolinska Institutet, opponent Kristoffer Hellstrand, Gothenburg University
  32. Michael Förster, 121027, "The Genetics of Experimental Arthritis in Rodents", Karolinska Institutet, opponent Göran Andersson, Swedish University of Agricultural Sciences, Uppsala
  33. Bruno Raposo, 121130, "Genetic Regulation of Autoantibodies in Arthritis: Lessons From Mouse Models". Karolinska Institutet, opponent Dan Holmberg, Cophenhagen University, Denmark
  34. Ingrid Lindh, 130412, "Autoantibody Recognition of Collagen Type II in Arthritis". Karolinska Institutet, opponent Leendert Trouw, Leiden University, Netherlands
  35. Tiina Kelkka, 130426, "Reactive oxygen species in inflammation", University of Turku, opponent Lars Ronnblom, Uppsala University, Sweden
  36. Jonatan Tuncel, 130601, "Functional and Genetic Analyses of the MHC and its impact on Autoimmunity in the Rat", Karolinska Institute, opponent Jacques Neefjes, Netherlands Cancer Institute, Netherlands
  37. Sabrina Haag, 140412, "The MHC and the Recognition of Self and Altered Self in Experimental and Rheumatoid Arthritis" Karolinska Institute, Lars Fugger, University of Oxford, UK                                          

Co-supervision:

Per Larsson (1989), Inga Hansson (1993), Ingrid Teige (2004), Jinan Li (2004), Meirav Holmdahl (2005), Jenny Karlsson (2005), Alexandra Treschow (2005), Patrick Merky (2011), Dorota Klaczkowska (2012), Ia Khmaladze (2014)

II. Awarded PhD Student (Johan Backlund)


Main supervision:

  1. Patrick Merky: 110120, "Posttranslational Modification of Collagen Type II", Karolinska Institutet, opponent Burkhard Becher, University Hospital of Zurich, Switzerland.

III. Awarded PhD Students (Kutty Selva Nandakumar)


Main supervision:

  1. Dorota Klaczkowska: 120523, "Finding Genes Controlling Arthritis in mice – Fcg Receptors and Complement C5", Karolinska Institutet, opponent Sejf Verbeek, Leiden University, Netherlands.
  2. Ia Khmaladze: 141208, "Understanding Inflammatory Mechanisms in Rheumatic Diseases",  Karolinska Institutet, opponent Ann Rothstein, University of Massachusetts Medical School, USA.

Co-supervision:

  1. Ingrid Lindh (2013)

Nan1

/ medinflam

Kutty Selva Nandakumar, Ph.D., Dr.Med.Sci.
Associate Professor (Docent)
Medical Inflammation Research, MBB, Karolinska Institute (KI)

&

Adjunct Faculty of University of Arkansas for Medical Sciences (UAMS)
Little Rock, USA

ADDRESS
Scheeles väg 2 B2, Plan 4, 171 77 Stockholm
Tel: 08-524   86533 (Direct), 0707432769 (mobile),
08-524   87715; 08-524   86337 (lab); Fax: 08-524 87750
e-mail: Nandakumar.Kutty-Selva @ ki.se

URL

EDUCATION

  • 2006 – Doctor of Medical Science (Dr.Med.Sci.) – Medical Inflammation Research – Medical Faculty – Lund University – Sweden
  • 1996 – Doctor of Philosophy (Ph.D.), Department of Immunology – School of Biological Sciences, Madurai Kamaraj University – India
  • 1988 – Master of Science (M.Sc.) – Department of  Medical Biochemistry – PGIBMS – University of Madras – India
  • 1986 – Bachelor of Science (B.Sc.) – Department of Chemistry – Sacred Heart College – University of Madras – India

LAB AND RESEARCH EXPERIENCE

  • Dec 2011 – Associate Professor – Medical Inflammation Research (MIR) – Department of Medical Biochemistry and Biophysics (MBB) – Karolinska Institute (KI) – Sweden
  • Nov  2008 – Nov 2011 – Assistant Professor – MIR – MBB –  KI – Sweden
  • July  2008 – Oct 2008 – Research Scientist – MIR – MBB –  KI – Sweden
  • April 2007 – June 2008 – Research Assistant – LUDC – Lund University (LU) – Sweden
  • Feb 2007 – Mar 2007 – Research Scientist – Hansa Medical AB – LU – Sweden
  • Feb 2006 – Jan 2007 – Research Scientist – Resistentia Pharmaceuticals AB – LU – Sweden
  • June 1998 – May 2001 – Postdoctoral Fellow – MIR – LU – Sweden
  • Jan 1996 – May 1998 – Postdoctoral Fellow – CCMB, India
  • 1988 – 1989 – Project Student – Department of Biochemistry, AIIMS –  India

PARTICIPANT IN EU PROJECTS

COMMISSION OF TRUST

EVALUATION OF PROJECT GRANTS

  • ARC grant (UK) – 2008, 2010, 2011, 2012 and 2014
  • KID grants (KI, Sweden) – VT & HT – 2012, VT & HT – 2013, VT & HT – 2014, 2015
  • Dutch Technology Foundation (STW, The Netherlands) – 2012

MEMBER OF THE EDITORIAL BOARD

  • Dataset Papers in Immunology
  • Dataset Papers in Rheumatology
  • Journal of BioScience and Biotechnology
  • WebMed Central
  • New Journal of Science
  • Autoimmune Diseases & Therapeutic Approaches

ADHOC REFEREE

  • Arthritis Research & Therapy (2004-2016)
  • Evidence-Based Complementary and Alternative Medicine (2016)
  • PLoS One (2015)
  • Journal of Inflammation (2015)
  • Journal of Immunology (2015)
  • International Journal of Biological Macromolecules (2015)
  • Expert Review on Vaccines (2014)
  • Expert Review of Molecular Diagnostics (2014)
  • Expert Review of Clinical Immunology (2014)
  • Journal of Biomaterials Science: Polymer Edition (2014)
  • Vaccines (2014)
  • Scandinavian Journal of Immunology (2010-14)
  • Annals of Rheumatic Diseases (2013)
  • International Journal of Environmental Research and Public Health (2013)
  • Medical Principles and Practice (2013)
  • Molecular Pharmaceutics (2013)
  • Current Organic Chemistry (2013)
  • Apoptosis (2013)
  • European Journal of Immunology (2006-2007, 2011-2012)
  • Langmuir (2009)
  • Mediators of Inflammation (2009)
  • Biotechnology Advances (2009)
  • BMC Musculoskeletal Disorders (2008)
  • Biomaterials (2008)
  • Cytokine (2008)
  • Cancer Biomarkers (2007)
  • Nature Protocols (2006)
  • Scandinavian Journal of Rheumatology (2005)

TEACHER TRAINING

  • 2015 – Open Networking and Learning Course (ONL141) – Karolinska Institute
  • 2014 – Teaching and Learning in Higher Education – Karolinska Institute
  • 2013 – Project leadership for Research leaders – Karolinska Institute
  • 2012 – Pedagogy for Doctoral supervisors – Karolinska Institute
  • 2012 – Web course for Supervisors – Karolinska Institute
  • 2011 – Teaching International Students – Karolinska Institute
  • 2009 – Advanced Course on Communication and Learning – Karolinska Institute
  • 2009 – Postgraduate Supervisor Training Course – Karolinska Institute
  • 2009 – Basic Course in Education for University Teachers – Karolinska Institute
  • 2002 – Basic Course on Oral Communication – Lund University

COURSE ORGANIZER

        (Oct 2011, Mar 2013, Mar 2014, Mar 2015, Mar 2016)

TEACHER

  • Disease models of autoimmunity (arthritis, lupus, asthma)
  • Immunology and genetics for biomedical students
  • Organic chemistry for undergraduate students (GOC)
  • Biochemistry for undergraduate students (MBK)

RESEARCH TRAINER (SHORT DURATION)

M.Sc. students: 4; Ph.D. students: 5; M.D. students: 2; BMA student: 1

JUDGING COMMITTEE CHAIRMAN (Ph.D. Dissertation)

  • Thomas Landgraff Hagglof (Feb 2016) -"iNKT cell regulation of B cell responses in inflammation", Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Sweden.
  • Peter Lundback (Apr 2015) – " HMGB1: Regulation of Inflammatory Functions and Therapeutic Blockade", Centre for Molecular Medicine, Karolinska Institute, Sweden.
  • Chengjun Sun (October 2014) – "A study of Biomarker analysis in association with type I diabetes and their shared features in Rheumatoid arthritis" – Department of Medicine, Karolinska Institute, Sweden

JUDGING COMMITTEE MEMBER (Ph.D. Dissertation)

  • Ann-Charlotte Andersson (Dec 2014) –  "Characterization of Novel Glomerular Proteins: Role in Physiology and Disease" –  Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Sweden.
  • Stephen Ochaya (March 2013) –  "Comparative genomics and Molecular characterization of N-alpha acetyl transferase in Trypanosomes for drug target identification" – Department of Cell and Molecular Biology, Karolinska Institute, Sweden
  • Lidia Ibáñez Torres (October 2012) – "Involvement of NADPH oxidase and Nrf2/HO-1 pathways in experimental models of arthritis and postmenopausal osteoporosis" –  Department of Pharmacology, University of Valencia, Valencia, Spain

JUDGING COMMITTEE MEMBER (Ph. D. Half-time Control)

  • Katarina Habir (February 2016) – "B cell subsets in autoimmune Disease" – Centre for Molecular Medicine, Karolinska Institute, Sweden.
  • Sevasti Flytzani (February 2013) – "Genetic Regulation of Neuroinflammation" – Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
  • Chengjun Sun (January 2014) – "A study of Biomarker analysis in association with type I diabetes and their shared features in Rheumatoid arthritis" – Department of Medicine, Karolinska Institute, Stockholm, Sweden

EVALUATOR (Ph.D. Dissertation)

  • R. Revathi (Mar 2015) – "Individual and synergetic effects of Umbelliferone with Vitamin C on N-nitrosodiethylamine induced hepatocellular carcinogenesis – an in vivo and in vitro study" – Department of Biochemistry, Periyar University, India.
  • M. Ragunath  (April 2014) – "Molecular mechanisms underlying chemopreventive activities of umbelliferone alone and with 5-flurouracil on 1,2-dimethylhydrazine induced colon carcinogenesis" – Periyar University, India
  • T. Prabu (August 2013) – "Naringin – A flavonone, attenuates liver carcinogenesis by NF-kB mediated apoptotic pathway – in vivo and in vitro studies" – Periyar University, India
  • Pankaj Masih (July 2013) – “Design, Synthesis and hyperglycemic activity of some novel Glitazones” –  JSS University, India

FACULTY OPPONENT

  • Ph.D. Dissertation – Mohammed Mullazehi (May 2009). "Anti-Collagen type II autoantibodies in an acute phenotype of early Rheumatoid arthritis". Department of Oncology, Radiology and Clinical Immunology, Uppsala University, Uppsala, Sweden

GRANT SOURCES

  • Alex and Eva Wallströms
  • AnneGreta Holger Crafoord
  • Department of Medical BIochemistry and Biophysics
  • Greta and Johan Kocks
  • Karolinska Institute (Fobi)
  • Karolinska Institute (KID)
  • Konung Gustaf V:s 80-Years
  • Lund University Diabetic Centre (LUDC)
  • Nanna Svartz
  • Rheumatikerforbundet
  • Swedish Research Council (VR-Medicine)
  • Swedish Research Council (VR-Link)
  • Tore Nilssons
  • Åke Wibergs
  • Österlunds

PATENTS

  • 2010 – Collin M, Allhorn M, Holmdahl R and Nandakumar KS – "Deglycosylated antibodies" – WIPO Patent Application WO/2010/057626
  • 2008 – Blom A, Holmdahl R and Nandakumar KS – "C4bp polypeptides and arthritis"
  • 2006 – Olsson A, Collin M, Bjorck L, Shannon O, holmdahl R and Nandakumar KS – "Therapeutic application of EndoS"
  • 2005 – Bjorck L, Holmdahl R and Nandakumar KS – "IdeS for treatment of IgG antibody mediated diseases and conditions in the areas of autoimmunity, hematology and transplantation" – Patent Number: WO2006131347: Publication Date: 2006-12-14