Rikard Holmdahl

Research in the Holmdahl group:

To obtain basic biological knowledge explaining the development of chronic inflammatory disorders (CID), such as rheumatoid arthritis and multiple sclerosis, we use experimental animal models. The goal is to identify prognostic markers and to establish new therapies for these diseases. During the next period we have the following more specific goals:

1) To identify new pathways that control pathogenic inflammation using an experimental animal platform.

2) To translate the identification of selected genes associated with human CID to the animal model platform and the knowledge of new selected pathways in the animal models to human CID’s.

3) To understand the role of MHC class II genes in explaining the immune specificity of autoimmune disease and to develop a new type of vaccination strategy for treatment of rheumatoid arthritis

4) To understand the new Ncf1 controlled oxygen burst pathway associated with severe inflammation and to develop a new type of anti-inflammatory treatment based on oxidants.

CV